Hax1tm1Jni
Targeted Allele Detail
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| Symbol: |
Hax1tm1Jni |
| Name: |
HCLS1 associated X-1; targeted mutation 1, James N Ihle |
| MGI ID: |
MGI:3777018 |
| Gene: |
Hax1 Location: Chr3:89902753-89906023 bp, - strand Genetic Position: Chr3, 39.19 cM, cytoband F2
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| Alliance: |
Hax1tm1Jni page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:132627
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The coding region was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on thymocyte extracts.
(J:132627)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129P2/OlaHsd * C57BL/6 | | | | involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 | | | | involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 | |
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| Phenotypes: |
| Affected Systems |
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behavior/neurological
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√
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adipsia
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√
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aphagia
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√
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abnormal motor capabilities/coordination/movement
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√
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impaired coordination
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√
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abnormal locomotor activation
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√
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cellular
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√
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increased neuron apoptosis
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√
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hematopoietic system
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√
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decreased bone marrow cell number
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√
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decreased leukocyte cell number
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√
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decreased neutrophil cell number
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√
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decreased lymphocyte cell number
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√
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decreased immature B cell number
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√
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decreased T cell number
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√
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decreased double-positive T cell number
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√
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decreased single-positive T cell number
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√
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immune system
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√
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decreased leukocyte cell number
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√
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decreased neutrophil cell number
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√
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decreased lymphocyte cell number
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√
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decreased immature B cell number
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√
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decreased T cell number
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√
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decreased double-positive T cell number
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√
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decreased single-positive T cell number
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√
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mortality/aging
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√
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√
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√
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premature death
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√
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√
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√
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nervous system
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√
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increased neuron apoptosis
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√
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astrocytosis
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Hax1 Mutation: |
36 strains or lines available
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| Original: |
J:132627 Chao JR, et al., Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature. 2008 Mar 6;452(7183):98-102 |
| All: |
7 reference(s) |
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Analysis Tools
