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Mmp17tm1Ski
Targeted Allele Detail
Summary
Symbol: Mmp17tm1Ski
Name: matrix metallopeptidase 17; targeted mutation 1, Motoharu Seiki
MGI ID: MGI:3777020
Synonyms: Mt4-mmp-, Mt4-mmpLacZ
Gene: Mmp17  Location: Chr5:129661233-129688163 bp, + strand  Genetic Position: Chr5, 68.18 cM
Alliance: Mmp17tm1Ski page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132553
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A lacZ cassette with a nuclear localization sequence and a PGK-gpt/neo cassette were inserted after the translation initiation site in the first exon and replaced part of the first exon through the first intron. The absence of endogenous transcript expression and the presence of a lacZ transcript was confirmed by RT-PCR on brain extracts. This is a null allele. (J:132553)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 104224 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp17 Mutation:  34 strains or lines available
References
Original:  J:132553 Rikimaru A, et al., Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase. Genes Cells. 2007 Sep;12(9):1091-100
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory