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Nanos3tm2(cre)Ysa
Targeted Allele Detail
Summary
Symbol: Nanos3tm2(cre)Ysa
Name: nanos C2HC-type zinc finger 3; targeted mutation 2, Yumiko Saga
MGI ID: MGI:3777592
Synonyms: Nanos3-Cre
Gene: Nanos3  Location: Chr8:84900359-84911396 bp, - strand  Genetic Position: Chr8, 40.45 cM
Alliance: Nanos3tm2(cre)Ysa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132711
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Nanos3tm2(cre)Ysa expression driven by 1 gene
 
Mutation details: The cre recombinase coding sequence and SV40 polyadenylation signal followed by an frt-flanked PGK-neo selection cassette (in the opposite orientation) was inserted into exon1 by homologous recombination of the Nanos3 gene in TT2 ES cells. Expression is detected at E7.75 in germ cells during the migration stage and after entry into the gonad. (J:136687)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nanos3 (mouse)
Summary of all recombinase alleles driven by Nanos3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nanos3 Mutation:  28 strains or lines available
References
Original:  J:132711 Suzuki A, et al., Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev. 2008 Feb 15;22(4):430-5
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory