Gt(ROSA)26Sor<tm1(cre/ERT2)Alj> Targeted Allele Detail MGI Mouse (MGI:3778915)

Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}
Targeted Allele Detail

Summary

Symbol:	Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Alexandra L Joyner
MGI ID:	MGI:3778915
Synonyms:	Gt(ROSA)26Sor^{tm1(cre/ESR1)Alj}, Rosa26^CreERT2, Rosa26CreERT2, Rosa26^CreERT2neo
Gene:	Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:133568
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj} expression driven by 1 gene

Mutation details: A Cre/ERT2 fusion and frt flanked neo cassette were inserted into the Rosa26 locus by homologous recombination. The neo cassette was removed by Flpe mediated recombination. (J:156169)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Alliance mouse Gt(ROSA)26Sor gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	993 strains or lines available

References

Original:	J:133568 Takeda K, et al., Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation. 2007 Aug 14;116(7):774-81
All:	13 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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