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Myf6tm2(cre)Mrc
Targeted Allele Detail
Summary
Symbol: Myf6tm2(cre)Mrc
Name: myogenic factor 6; targeted mutation 2, Mario R Capecchi
MGI ID: MGI:3783305
Synonyms: Myf6-ICN-, Myf6-ICNp
Gene: Myf6  Location: Chr10:107328709-107330584 bp, - strand  Genetic Position: Chr10, 55.96 cM
Alliance: Myf6tm2(cre)Mrc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93444
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph, Recombinase)
Mutation:    Insertion
 
Myf6tm2(cre)Mrc expression driven by 1 gene
 
Mutation details: An IRES-Cre and frt-flanked neo cassette were inserted in the 3' UTR to allow bicistronic expression of Myf6 and Cre. Myf6tm1(cre)Mrc was generated from this allele. Reduced transcript expression was confirmed by semi-quantitative RT-PCR at E12.5. This allele is a hypomorph. (J:93444)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Myf6 (mouse)
Summary of all recombinase alleles driven by Myf6.
 

Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Myf6tm2(cre)Mrc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myf6 Mutation:  19 strains or lines available
References
Original:  J:93444 Keller C, et al., Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Dec 1;18(21):2614-26
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory