Pbx1<tm2Mlc> Targeted Allele Detail MGI Mouse (MGI:3783739)

Pbx1^tm2Mlc
Targeted Allele Detail

Summary

Symbol:	Pbx1^tm2Mlc
Name:	pre B cell leukemia homeobox 1; targeted mutation 2, Micheal L Cleary
MGI ID:	MGI:3783739
Gene:	Pbx1 Location: Chr1:167946933-168259839 bp, - strand Genetic Position: Chr1, 75.95 cM
Alliance:	Pbx1^tm2Mlc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:132963
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: ES cells containing one null Pbx1^tm1Mlc allele were used in a second targeting event. The remaining wild-type allele was targeted by inserting a loxP site upstream of exon 3 and a loxP site and hygromycin-GFP fusion cassette downstream of exon 3. (J:132963)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Pbx1 Mutation:	40 strains or lines available

References

Original:	J:132963 Sanyal M, et al., B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood. 2007 May 15;109(10):4191-9
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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