About   Help   FAQ
Mus81tm1Esse
Targeted Allele Detail
Summary
Symbol: Mus81tm1Esse
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Jeroen Essers
MGI ID: MGI:3785405
Synonyms: Efemp2/Mus81tm1Esse, Fibulin-4R
Gene: Mus81  Location: Chr19:5532589-5538461 bp, - strand  Genetic Position: Chr19, 4.34 cM
Alliance: Mus81tm1Esse page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133703
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 1 through 10 of Mus81 were replaced with a neo cassette. Reduction in expression of transcripts for both Mus81 and the neighboring gene Efemp2 was confirmed by quantitative RT-PCR on embryonic fibroblasts extracts. (J:133703)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mus81 Mutation:  31 strains or lines available
References
Original:  J:133703 Hanada K, et al., Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res. 2007 Mar 16;100(5):738-46
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory