Fermt3<tm1Ref> Targeted Allele Detail MGI Mouse (MGI:3785479)

Fermt3^tm1Ref
Targeted Allele Detail

Summary

Symbol:	Fermt3^tm1Ref
Name:	fermitin family member 3; targeted mutation 1, Reinhard Fassler
MGI ID:	MGI:3785479
Synonyms:	Kind3^-, Kindlin-3^-
Gene:	Fermt3 Location: Chr19:6976326-6996837 bp, - strand Genetic Position: Chr19, 5.13 cM
Alliance:	Fermt3^tm1Ref page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:133659
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 3 through 6 was replaced with an IRES/lacZ/neo cassette. The absence of protein product was confirmed by western blot analysis on spleen and platelet extracts. This is a reporter and null allele. (J:133659)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fermt3 Mutation:	31 strains or lines available

References

Original:	J:133659 Moser M, et al., Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med. 2008 Mar;14(3):325-30
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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