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Hrgtm1Wja
Targeted Allele Detail
Summary
Symbol: Hrgtm1Wja
Name: histidine-rich glycoprotein; targeted mutation 1, Willi Jahnen-Dechent
MGI ID: MGI:3789962
Gene: Hrg  Location: Chr16:22769822-22780406 bp, + strand  Genetic Position: Chr16, 13.79 cM
Alliance: Hrgtm1Wja page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134621
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 1.8 kb fragment including the translation start site was replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein in serum from homozygous mice. (J:134621)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hrg Mutation:  33 strains or lines available
References
Original:  J:134621 Tsuchida-Straeten N, et al., Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG). J Thromb Haemost. 2005 May;3(5):865-72
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory