Rr160tm1Wtg
Targeted Allele Detail
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| Symbol: |
Rr160tm1Wtg |
| Name: |
regulatory region 160; targeted mutation 1, William T Garrard |
| MGI ID: |
MGI:3790771 |
| Synonyms: |
Ed-, Igktm1Wtg |
| Gene: |
Rr160 Location: unknown Genetic Position: Chr6, Syntenic
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| Alliance: |
Rr160tm1Wtg page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:134885
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| Parent Cell Line: |
SM1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Modified regulatory region, Null/knockout) |
| Mutations: |
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Insertion, Intergenic deletion
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Mutation details: An enhancer element that lies far downstream of the C-kappa gene segment was targeted by homologous recombination. This "further downstream enhancer element" (Ed) is located 8 kb downstream from another downstream enhancer, the E3' enhancer element (Rr159). The 1.2kb Ed element was flanked by loxP sites with a floxed neomycin selection cassette also being placed immediately downstream. Founder mice were bred with cre transgenic mice to remove the Ed element and the selection cassette. Deletion of the Ed element was confirmed through Southern blotting.
(J:134885)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Rr160 Mutation: |
0 strains or lines available
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| Original: |
J:134885 Xiang Y, et al., The Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation. J Immunol. 2008 May 15;180(10):6725-32 |
| All: |
4 reference(s) |
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Analysis Tools
