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Fgf16tm1.1(cre)Sms
Targeted Allele Detail
Summary
Symbol: Fgf16tm1.1(cre)Sms
Name: fibroblast growth factor 16; targeted mutation 1.1, Suzanne L Monsour
MGI ID: MGI:3790784
Synonyms: Fgf16IRESCre
Gene: Fgf16  Location: ChrX:104807885-104818545 bp, + strand  Genetic Position: ChrX, 47.2 cM, cytoband C3
Alliance: Fgf16tm1.1(cre)Sms page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139718
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Fgf16tm1.1(cre)Sms expression driven by 1 gene
 
Mutation details: Cre recombinase is expressed from this allele under control of the endogenous Fgf16 promoter in the developing cristae and spiral prominence epithelial precursors of the inner ear. The Cre recombinase coding sequence, preceded by an internal ribosomal entry site (IRES) and followed by a single frt site (marking the site of excision of a frt-flanked neomycin resistance cassette), interrupts the first exon of Fgf16 so that codon 63 is disrupted. (J:139718)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Fgf16 (mouse)
Summary of all recombinase alleles driven by Fgf16.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf16 Mutation:  7 strains or lines available
Notes
This allele was derived from Fgf16tm1(cre)Sms, mutants for which have been characterized phenotypically, by crossing mice bearing that allele with FLPe-expressing animals.
References
Original:  J:139718 Hatch EP, et al., Fgf16(IRESCre) mice: a tool to inactivate genes expressed in inner ear cristae and spiral prominence epithelium. Dev Dyn. 2009 Feb;238(2):358-66
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory