Ror2<tm1Anec> Targeted Allele Detail MGI Mouse (MGI:3793279)

Ror2^tm1Anec
Targeted Allele Detail

Summary

Symbol:	Ror2^tm1Anec
Name:	receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, Aris N Economides
MGI ID:	MGI:3793279
Synonyms:	Ror2^W749FLAG, Ror2^W749X
Gene:	Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
Alliance:	Ror2^tm1Anec page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:134490
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted
Mutations:		Insertion, Intragenic deletion
		Mutation details: The region encoding W749 to D930 was replaced with a fused, in-frame FLAG-encoding sequence followed by a neo cassette. RT-PCR confirmed the absence of wild-type transcript and the presence of the tagged truncated product in E15.5 embryos. (J:134490)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ror2 Mutation:	125 strains or lines available

References

Original:	J:134490 Raz R, et al., The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development. 2008 May;135(9):1713-23
All:	4 reference(s)

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