About   Help   FAQ
Mapttm2(cre)Aha
Targeted Allele Detail
Summary
Symbol: Mapttm2(cre)Aha
Name: microtubule-associated protein tau; targeted mutation 2, Akihiro Harada
MGI ID: MGI:3793311
Synonyms: tau-Cre
Gene: Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance: Mapttm2(cre)Aha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134499
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mapttm2(cre)Aha expression driven by 1 gene
 
Mutation details: A cre gene with a nuclear localization signal followed by an frt-flanked neo cassette was inserted immediately after the start methionine. Cre function is dectected in neurons of almost all areas of the brain with only granule cells in the caudal part of the cerebellum not exhbiting cre function. Other organs such as the liver, kidney and intestine do not exhibit cre function. (J:134499)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mapt (mouse)
Summary of all recombinase alleles driven by Mapt.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  430 strains or lines available
References
Original:  J:134499 Muramatsu K, et al., Neuron-specific recombination by Cre recombinase inserted into the murine tau locus. Biochem Biophys Res Commun. 2008 Jun 6;370(3):419-23
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory