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Gt(ROSA)26Sortm2(icre/ERT2)Jphe
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2(icre/ERT2)Jphe
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jean-Paul Herman
MGI ID: MGI:3793441
Synonyms: Cre2ERT2, ERT2-iCre-ERT2, Gt(ROSA)26Sortm2(cre/ESR1)Jphe
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2(icre/ERT2)Jphe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135150
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gt(ROSA)26Sortm2(icre/ERT2)Jphe expression driven by 1 gene
 
Mutation details: A humanized cre gene flanked by 2 tamoxifen-binding domains (ERT2-icre-ERT2) and followed by an frt-flanked hygro cassette was knocked into the locus. Inducible cre expression is present in all cells following treatment with tamoxifen with only the brain exhibiting decresed expression levels. (J:135150)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor (mouse)
Summary of all recombinase alleles driven by Gt(ROSA)26Sor.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:135150 Jullien N, et al., Use of ERT2-iCre-ERT2 for conditional transgenesis. Genesis. 2008 Apr;46(4):193-9
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory