Pdpk1tm1Dral
Targeted Allele Detail
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| Symbol: |
Pdpk1tm1Dral |
| Name: |
3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Dario R Alessi |
| MGI ID: |
MGI:3795190 |
| Synonyms: |
PDK1K465E |
| Gene: |
Pdpk1 Location: Chr17:24292654-24369898 bp, - strand Genetic Position: Chr17, 12.23 cM, cytoband A3.3
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| Alliance: |
Pdpk1tm1Dral page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:136089
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Not Applicable) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 12 wass replaced with a floxed neo cassette and an exon 12 containing a nucleotide substitution that results in the amino acid substitution of glutamic acid for lysine at position 465 (K465E). The neo cassette was removed by germ line, cre-mediated recombination.
(J:136089)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | | |
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| Phenotypes: |
| Affected Systems |
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endocrine/exocrine glands
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√
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√
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decreased adrenal gland zona fasciculata size
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√
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√
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pancreatic islet hyperplasia
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√
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√
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pancreatic islet hypoplasia
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√
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√
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small pancreas
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√
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√
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small testis
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√
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growth/size/body
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√
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√
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decreased body weight
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√
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√
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hematopoietic system
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√
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√
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small spleen
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√
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√
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homeostasis/metabolism
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√
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√
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increased circulating insulin level
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√
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√
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impaired glucose tolerance
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√
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√
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insulin resistance
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√
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√
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immune system
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√
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√
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small spleen
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√
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√
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nervous system
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√
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√
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decreased brain size
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√
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√
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renal/urinary system
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√
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√
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abnormal kidney size
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√
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√
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reproductive system
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√
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small testis
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pdpk1 Mutation: |
138 strains or lines available
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| Original: |
J:136089 Bayascas JR, et al., Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol. 2008 May;28(10):3258-72 |
| All: |
8 reference(s) |
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Analysis Tools
