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Pdpk1tm1Dral
Targeted Allele Detail
Summary
Symbol: Pdpk1tm1Dral
Name: 3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Dario R Alessi
MGI ID: MGI:3795190
Synonyms: PDK1K465E
Gene: Pdpk1  Location: Chr17:24292654-24369898 bp, - strand  Genetic Position: Chr17, 12.23 cM, cytoband A3.3
Alliance: Pdpk1tm1Dral page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136089
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details: Exon 12 wass replaced with a floxed neo cassette and an exon 12 containing a nucleotide substitution that results in the amino acid substitution of glutamic acid for lysine at position 465 (K465E). The neo cassette was removed by germ line, cre-mediated recombination. (J:136089)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 42 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Pdpk1tm1Dral
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdpk1 Mutation:  138 strains or lines available
References
Original:  J:136089 Bayascas JR, et al., Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol. 2008 May;28(10):3258-72
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory