Trp63<tm1Aam> Targeted Allele Detail MGI Mouse (MGI:3795257)

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Trp63^tm1Aam
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Trp63^tm1Aam
Name:	transformation related protein 63; targeted mutation 1, Alea A Mills
MGI ID:	MGI:3795257
Synonyms:	p63^EEC, Trp63^R279H
Gene:	Trp63 Location: Chr16:25502513-25710842 bp, + strand Genetic Position: Chr16, 17.37 cM
Alliance:	Trp63^tm1Aam page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:135784
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted
Mutation:		Nucleotide substitutions
		Mutation details: This allele is modified such that histidine is substituted for arginine at position 279. (details unpublished) (J:135784)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Trp63 Mutation:	60 strains or lines available

References

Original:	J:135784 Lo Iacono N, et al., Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development. 2008 Apr;135(7):1377-88
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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