Vamp2<tm1(cre/ERT)Nat> Targeted Allele Detail MGI Mouse (MGI:3795865)

Vamp2^{tm1(cre/ERT)Nat}
Targeted Allele Detail

Summary

Symbol:	Vamp2^{tm1(cre/ERT)Nat}
Name:	vesicle-associated membrane protein 2; targeted mutation 1, Jeremy Nathans
MGI ID:	MGI:3795865
Synonyms:	VAMP2-IRES-creER, Vamp2^{tm1(cre/Esr1)Nat}
Gene:	Vamp2 Location: Chr11:68979354-68983207 bp, + strand Genetic Position: Chr11, 42.36 cM
Alliance:	Vamp2^{tm1(cre/ERT)Nat} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:144315
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Vamp2^{tm1(cre/ERT)Nat} expression driven by 1 gene

Mutation details: An IRES-creER cassette, a tetracycline resistance gene and a Frt-flanked neomycin selection marker were all knocked in to the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, cre expression was detected in a wide variety of neural and glial cells of the brain. This is line B4. (J:144315)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Vamp2 (mouse) Summary of all recombinase alleles driven by Vamp2. Comparative matrix view of recombinase activities Alliance mouse Vamp2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Vamp2 Mutation:	20 strains or lines available

References

Original:	J:144315 Rotolo T, et al., Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology. PLoS One. 2008;3(12):e4099
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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