Th<tm1(cre/Esr1)Nat> Targeted Allele Detail MGI Mouse (MGI:3795871)

Th^{tm1(cre/Esr1)Nat}
Targeted Allele Detail

Summary

Symbol:	Th^{tm1(cre/Esr1)Nat}
Name:	tyrosine hydroxylase; targeted mutation 1, Jeremy Nathans
MGI ID:	MGI:3795871
Synonyms:	TH^CreER, TH^iCreER, TH-IRES-creER, TH-IRES-creER line C2, Th^{tm1(cre/ERT)Nat}, Th^{tm1(cre/Esr1)Nat}
Gene:	Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
Alliance:	Th^{tm1(cre/Esr1)Nat} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:144315
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Th^{tm1(cre/Esr1)Nat} expression driven by 1 gene

Mutation details: An IRES-creER cassette, a tetracycline resistance gene, and an FRT-flanked neomycin selection marker were all knocked into the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, cre expression was detected in a sparse number of dopaminergic neurons in the brain. This is line C2. (J:144315)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Th (mouse) Summary of all recombinase alleles driven by Th. Comparative matrix view of recombinase activities Alliance mouse Th gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Th Mutation:	58 strains or lines available

References

Original:	J:144315 Rotolo T, et al., Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology. PLoS One. 2008;3(12):e4099
All:	21 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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