Neurog3tm1(Neurog3,cre/ERT)Ggu
Targeted Allele Detail
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| Symbol: |
Neurog3tm1(Neurog3,cre/ERT)Ggu |
| Name: |
neurogenin 3; targeted mutation 1, Guoqiang Gu |
| MGI ID: |
MGI:3796205 |
| Synonyms: |
Neurog3FLOX, Neurog3tm1(cre/ERT)Ggu, Neurog3tm1(cre/ESR1)Ggu, Ngn3F |
| Gene: |
Neurog3 Location: Chr10:61968869-61970542 bp, + strand Genetic Position: Chr10, 32.35 cM, cytoband B4
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| Alliance: |
Neurog3tm1(Neurog3,cre/ERT)Ggu page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:136131
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| Parent Cell Line: |
TL1/TL-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Conditional ready, Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Neurog3tm1(Neurog3,cre/ERT)Ggu expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Neurog3 (MGI:893591) |
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Mutation details: A cassette containing a floxed version of the open reading frame followed by a cre/ERT fusion gene was inserted to replace the endogenous gene. This allele expresses a normal Neurog3 protein unless exposed to Cre recombinase, which then causes recombination of the loxP sites and expression of the cre/ERT fusion.
(J:136131)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Neurog3
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Neurog3 Mutation: |
19 strains or lines available
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| Original: |
J:136131 Wang S, et al., Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol. 2008 May 15;317(2):531-40 |
| All: |
5 reference(s) |
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Analysis Tools
