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Neurog3tm1.1(cre/ERT)Ggu
Targeted Allele Detail
Summary
Symbol: Neurog3tm1.1(cre/ERT)Ggu
Name: neurogenin 3; targeted mutation 1.1, Guoqiang Gu
MGI ID: MGI:3796207
Synonyms: Neurog3CreERT, Neurog3tm1.1(cre/ESR1)Ggu, Ngn3-
Gene: Neurog3  Location: Chr10:61968869-61970542 bp, + strand  Genetic Position: Chr10, 32.35 cM, cytoband B4
Alliance: Neurog3tm1.1(cre/ERT)Ggu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136131
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Neurog3tm1.1(cre/ERT)Ggu expression driven by 1 gene
 
Mutation details: Cre mediated recombination was used to remove the floxed open reading frame leaving the cre/ESR1 fusion intact. Neurog3 expression is abolished and the cre/ERT fusion protein is expressed under the control of the endogenous Neurog3 promoter. (J:136131)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Neurog3 (mouse)
Summary of all recombinase alleles driven by Neurog3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurog3 Mutation:  19 strains or lines available
References
Original:  J:136131 Wang S, et al., Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol. 2008 May 15;317(2):531-40
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory