Ibsp<tm1Jeau> Targeted Allele Detail MGI Mouse (MGI:3796255)

About Help FAQ

Ibsp^tm1Jeau
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ibsp^tm1Jeau
Name:	integrin binding sialoprotein; targeted mutation 1, Jane E Aubin
MGI ID:	MGI:3796255
Synonyms:	BSP^-
Gene:	Ibsp Location: Chr5:104447153-104459338 bp, + strand Genetic Position: Chr5, 50.68 cM
Alliance:	Ibsp^tm1Jeau page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:136223
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 2 and 3 were replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on femur extracts. (J:136223)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ibsp Mutation:	35 strains or lines available

References

Original:	J:136223 Malaval L, et al., Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. J Exp Med. 2008 May 12;205(5):1145-53
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24