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Tg(Tg-cre)1Soff
Transgene Detail
Summary
Symbol: Tg(Tg-cre)1Soff
Name: transgene insertion 1, Stefan Offermanns
MGI ID: MGI:3796561
Synonyms: Tg-cre
Transgene: Tg(Tg-cre)1Soff  Location: unknown  
Alliance: Tg(Tg-cre)1Soff page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Tg-cre)1Soff expression driven by 1 gene
 
Mutation details: A transgenic construct with the coding sequence of the iCre recombinase followed by the bovine GH polyadenylation signal and a frt-flanked ampicillin cassette was fused to sequences from the proximal promoter and first intron of the mouse thyroglobulin (Tg) gene. The whole construct was introduced into the PAC encoding the Tg gene and by homologous recombination, the ATG of the iCre replaced the ATG of the thryoglobulin gene. The ampicillin cassette was removed by Flp-mediated recombination. Cre activity is observed in nearly all thyrocytes, but not in other cells of the thryoid gland after E10.5. (J:127484)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tg (mouse)
Summary of all recombinase alleles driven by Tg.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:127484 Kero J, et al., Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development. J Clin Invest. 2007 Sep;117(9):2399-407
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory