Bmp4<tm4Blh> Targeted Allele Detail MGI Mouse (MGI:3797048)

Bmp4^tm4Blh
Targeted Allele Detail

Summary

Symbol:	Bmp4^tm4Blh
Name:	bone morphogenetic protein 4; targeted mutation 4, Brigid L Hogan
MGI ID:	MGI:3797048
Synonyms:	Bmp4^loxP
Gene:	Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
Alliance:	Bmp4^tm4Blh page

Hindlimb fusion of Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:136636
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted into introns 2 and 4. An frt-flanked neo cassette used for selection was removed by germ line, flp-mediated recombination. (J:136636)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	62 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:	23 strains or lines available

References

Original:	J:136636 Chang W, et al., Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet. 2008 Apr;4(4):e1000050
All:	19 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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