Opn4<tm1(cre)Sapa> Targeted Allele Detail MGI Mouse (MGI:3798479)

Opn4^tm1(cre)Sapa
Targeted Allele Detail

Summary

Symbol:	Opn4^tm1(cre)Sapa
Name:	opsin 4 (melanopsin); targeted mutation 1, Satchidananda Panda
MGI ID:	MGI:3798479
Synonyms:	mOpn4-Cre1D4, Opn4^Cre
Gene:	Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
Alliance:	Opn4^tm1(cre)Sapa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:137151
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutations:

Insertion, Intragenic deletion

Opn4^tm1(cre)Sapa expression driven by 1 gene

Mutation details: The first 7 exons were replaced with a cassette containing a cre gene, IRES/betaTau, a floxed neo and eYFP gene. No YFP expression was detected in the retina. Cre activity is detected in the retinal ganglion cell layer. (J:137151)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Opn4 (mouse) Summary of all recombinase alleles driven by Opn4. Comparative matrix view of recombinase activities Alliance mouse Opn4 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Opn4 Mutation:	33 strains or lines available

References

Original:	J:137151 Hatori M, et al., Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS One. 2008;3(6):e2451
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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