Gli3<tm1Alj> Targeted Allele Detail MGI Mouse (MGI:3798847)

Gli3^tm1Alj
Targeted Allele Detail

Summary

Symbol:	Gli3^tm1Alj
Name:	GLI-Kruppel family member GLI3; targeted mutation 1, Alexandra L Joyner
MGI ID:	MGI:3798847
Synonyms:	Gli3^F, Gli3^flox
Gene:	Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
Alliance:	Gli3^tm1Alj page

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:137136
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: An FRT site flanked neomycin resistance gene cassette with a 5' loxP site was inserted upstream of exon 8 and an additional loxP site was inserted downstream of exon 8. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 8 floxed. (J:137136)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Gli3 Mutation:	81 strains or lines available

References

Original:	J:137136 Blaess S, et al., Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development. 2008 Jun;135(12):2093-103
All:	29 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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