Rfx4<m269Asp> Chemically induced Allele Detail MGI Mouse (MGI:3799278)

Rfx4^m269Asp
Chemically induced Allele Detail

Summary

Symbol:	Rfx4^m269Asp
Name:	regulatory factor X, 4 (influences HLA class II expression); mutation 269, Andrew S Peterson
MGI ID:	MGI:3799278
Synonyms:	Rfx4^L298P, Rfx4^line269
Gene:	Rfx4 Location: Chr10:84591926-84742402 bp, + strand Genetic Position: Chr10, 41.63 cM, cytoband C1
Alliance:	Rfx4^m269Asp page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: ENU mutagenesis induced nucleotide transition that resulted in an amino acid substitution of proline for leucine in the C dimerization domain. (J:136795)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Rfx4 Mutation:	48 strains or lines available

References

Original:	J:136795 Zarbalis K, et al., A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug;2(8):E219
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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