Traddtm1.1Mpa
Targeted Allele Detail
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|
| Symbol: |
Traddtm1.1Mpa |
| Name: |
TNFRSF1A-associated via death domain; targeted mutation 1.1, Manolis Pasparakis |
| MGI ID: |
MGI:3799300 |
| Gene: |
Tradd Location: Chr8:105985207-105991226 bp, - strand Genetic Position: Chr8, 53.04 cM
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| Alliance: |
Traddtm1.1Mpa page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:139030
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| Parent Cell Line: |
Bruce 4 (ES Cell)
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| Strain of Origin: |
B6.Cg-Thy1a
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 3.4 kb fragment including all coding exons (exons 2- 5) was flanked with loxP sites and an adenoviral splice acceptor site fused to a cDNA encoding eGFP was inserted downstream of the second loxP site. In vivo cre-mediated recombination resulted in deletion of exons 2-5 and expression of eGFP under control of the endogenous promoter.
(J:139030)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: BALB/cJ * C57BL/6 | | | | involves: C57BL/6 | | | | involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 | |
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| Phenotypes: |
| Affected Systems |
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hematopoietic system
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√
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abnormal spleen germinal center morphology
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√
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decreased IgG level
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√
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homeostasis/metabolism
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√
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√
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decreased circulating tumor necrosis factor level
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√
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√
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abnormal interleukin level
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√
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decreased physiological sensitivity to xenobiotic
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√
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immune system
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√
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√
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√
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abnormal spleen germinal center morphology
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√
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decreased IgG level
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√
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decreased circulating tumor necrosis factor level
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√
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√
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abnormal interleukin level
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√
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decreased interferon-beta secretion
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√
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increased susceptibility to bacterial infection
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tradd Mutation: |
18 strains or lines available
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|
| Original: |
J:139030 Ermolaeva MA, et al., Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol. 2008 Sep;9(9):1037-46 |
| All: |
3 reference(s) |
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Analysis Tools
