Palb2<Gt(CG0691)Wtsi> Gene trapped Allele Detail MGI Mouse (MGI:3801303)

Palb2^{Gt(CG0691)Wtsi}
Gene trapped Allele Detail

Summary

Symbol:	Palb2^{Gt(CG0691)Wtsi}
Name:	partner and localizer of BRCA2; gene trap CG0691, Wellcome Trust Sanger Institute
MGI ID:	MGI:3801303
Synonyms:	Palb2^GT
Gene:	Palb2 Location: Chr7:121706485-121732203 bp, - strand Genetic Position: Chr7, 65.42 cM
Alliance:	Palb2^{Gt(CG0691)Wtsi} page

Mutation
origin

Mutant Cell Line:	CG0691
Germline Transmission:	Earliest citation of germline transmission: J:161528
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT0lxrT2

Mutation details: The gene trap vector inserted into intron 1 resulting in the production of an exon 1 - beta-gal fusion protein. Quantitative RT-PCR confirmed the absence of expression in homozygous embryos. (J:161528)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Palb2^{Gt(CG0691)Wtsi}

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Palb2 Mutation:	50 strains or lines available

References

Original:	J:161528 Rantakari P, et al., Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet. 2010 Aug 1;19(15):3021-9
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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