Nfix<tm1Rmg> Targeted Allele Detail MGI Mouse (MGI:3802570)

Nfix^tm1Rmg
Targeted Allele Detail

Summary

Symbol:	Nfix^tm1Rmg
Name:	nuclear factor I/X; targeted mutation 1, Richard M Gronostajski
MGI ID:	MGI:3802570
Synonyms:	Nfix^c
Gene:	Nfix Location: Chr8:85431341-85527086 bp, - strand Genetic Position: Chr8, 41.02 cM, cytoband C1-C2
Alliance:	Nfix^tm1Rmg page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:137651
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Conditional ready, Hypomorph)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. The presence of the neomycin resistance gene reduces Nfix expression by 20-30%. (J:137651)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Nfix Mutation:	61 strains or lines available

References

Original:	J:137651 Campbell CE, et al., The transcription factor Nfix is essential for normal brain development. BMC Dev Biol. 2008;8:52
All:	17 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24