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Bmi1tm1(cre/ERT)Mrc
Targeted Allele Detail
Summary
Symbol: Bmi1tm1(cre/ERT)Mrc
Name: Bmi1 polycomb ring finger oncogene; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:3805814
Synonyms: Bmi1CreER, Bmi1tm1(cre/ESR1)Mrc
Gene: Bmi1  Location: Chr2:18681953-18691440 bp, + strand  Genetic Position: Chr2, 12.9 cM
Alliance: Bmi1tm1(cre/ERT)Mrc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138364
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Bmi1tm1(cre/ERT)Mrc expression driven by 1 gene
 
Mutation details: An IRES followed by a cre/ERT fusion and an frt-flanked neo cassette was inserted downstream of the translation stop codon. Germ line, flp-mediated recombination was used to remove the neo cassette. (J:138364)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Bmi1 (mouse)
Summary of all recombinase alleles driven by Bmi1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bmi1 Mutation:  31 strains or lines available
References
Original:  J:138364 Sangiorgi E, et al., Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet. 2008 Jul;40(7):915-20
All:  47 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory