Tg(Kap-icre)29066/2Sig
Transgene Detail
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| Symbol: |
Tg(Kap-icre)29066/2Sig |
| Name: |
transgene insertion 29066/2, Curt Sigmund |
| MGI ID: |
MGI:3806307 |
| Synonyms: |
KAP2-iCre, Tg(Kap-cre)29066/2Sig |
| Transgene: |
Tg(Kap-icre)29066/2Sig Location: unknown
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| Alliance: |
Tg(Kap-icre)29066/2Sig page
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| Strain of Origin: |
C57BL/6J x SJL
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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androgen |
| Mutation: |
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Insertion
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Tg(Kap-icre)29066/2Sig expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Kap |
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Mutation details: The Kap promoter and the distal regulatory sequences of the human angiotensinogen gene (AGT), which together confer androgen responsiveness, is used to drive expression of androgen-inducible improved Cre (iCre) in the kidney. The icre cDNA was cloned downstream of the Kap promoter (nucleotides -1542 through -1 relative to the transcription initiation site) into the NotI site of the pKAP2 vector. This is followed by the last 42 bp of human AGT exon 2 through exon 5, which lost their coding potential owing to the lack of the first 817 bp of exon 2 that included the ATG start site. Twenty-six founders were created of which only line 29066/2 expressed cre in male kidneys with some expression in the brain, liver, and heart.
(J:137742)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Kap
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:137742 Li H, et al., An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1481-6 |
| All: |
15 reference(s) |
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Analysis Tools
