Hes1<tm1Kag> Targeted Allele Detail MGI Mouse (MGI:3808031)

Hes1^tm1Kag
Targeted Allele Detail

Summary

Symbol:	Hes1^tm1Kag
Name:	hes family bHLH transcription factor 1; targeted mutation 1, Ryoichiro Kageyama
MGI ID:	MGI:3808031
Synonyms:	Hes1^f, Hes1^tm1Imayo
Gene:	Hes1 Location: Chr16:29883259-29886614 bp, + strand Genetic Position: Chr16, 21.09 cM
Alliance:	Hes1^tm1Kag page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:139170
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted after the first coding exon and a floxed neo cassette was inserted after the last coding exon. Expression of cre in ES cells was used to remove the neo cssette leaving coding exons 2 through 4 floxed. (J:139170)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

28 assay results

Tumor Data

List all tumor models in MMHCdb carrying Hes1^tm1Kag

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Hes1 Mutation:	23 strains or lines available

References

Original:	J:139170 Imayoshi I, et al., Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development. 2008 Aug;135(15):2531-41
All:	45 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24