Col2a1<Rgsc856> Chemically induced Allele Detail MGI Mouse (MGI:3808759)

Col2a1^Rgsc856
Chemically induced Allele Detail

Summary

Symbol:	Col2a1^Rgsc856
Name:	collagen, type II, alpha 1; RIKEN Genomic Sciences Center (GSC), 856
MGI ID:	MGI:3808759
Synonyms:	M100856
Gene:	Col2a1 Location: Chr15:97873483-97902525 bp, - strand Genetic Position: Chr15, 53.97 cM
Alliance:	Col2a1^Rgsc856 page

Skeletal abnormalities in Col2a1^Rgsc856/Col2a1⁺ and Col2a1^Rgsc856/Col2a1^Rgsc856 mice at E18.5

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:	C57BL/6JJcl
Project Collection:	RIKEN GSC ENU Project

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: ENU induced an A to C missense mutation at position 4406 which is predicted to cause an aspartic acid to alanine substitution at position 1469. This mutation is located in the coding region of the C-propeptide. (J:171906)
Inheritance:		Dominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Col2a1 Mutation:	69 strains or lines available

References

Original:	J:133634 RIKEN BioResource Center/RIKEN Genomic Sciences Center, A Large Scale Mutagenesis Program in RIKEN GSC. PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/). 2008;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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