Fmr1<tm1.2Cidz> Targeted Allele Detail MGI Mouse (MGI:3808885)

Fmr1^tm1.2Cidz
Targeted Allele Detail

Summary

Symbol:	Fmr1^tm1.2Cidz
Name:	fragile X messenger ribonucleoprotein 1; targeted mutation 1.2, Chris I de Zeeuw
MGI ID:	MGI:3808885
Synonyms:	Fmr1 KO2
Gene:	Fmr1 Location: ChrX:67722147-67761569 bp, + strand Genetic Position: ChrX, 34.83 cM
Alliance:	Fmr1^tm1.2Cidz page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:108008
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: A germline null mutation was created by crossing Fmr1 mice, which have the first coding exon floxed, with mice that express cre-recombinase in the germline (Tg(CAG-cre)13Miya). Gene inactivation was confirmed by a lack of protein expression in the brain and testes as determined by immunoblot analysis. (J:108008)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fmr1 Mutation:	29 strains or lines available

References

Original:	J:108008 Mientjes EJ, et al., The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis. 2006 Mar;21(3):549-55
All:	48 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24