Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Olig2tm2(TVA,cre)Rth
Name:	oligodendrocyte transcription factor 2; targeted mutation 2, David H Rowitch
MGI ID:	MGI:3810299
Synonyms:	Olig2-tva-cre
Gene:	Olig2  Location: Chr16:91022345-91025565 bp, + strand  Genetic Position: Chr16, 52.6 cM
Alliance:	Olig2tm2(TVA,cre)Rth page

Germline Transmission:	Earliest citation of germline transmission: J:139574
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Olig2tm2(TVA,cre)Rth expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Olig2 (MGI:1355331)   Mutation details: A cDNA encoding the avian specific retroviral receptor (TVA) followed by an IRES-cre and neo cassette was inserted immediately downstream of the translation initiation site. (J:139574)

Activity:	Tissue activity of this recombinase allele
Driver:	Olig2 (mouse) Summary of all recombinase alleles driven by Olig2. Alliance mouse Olig2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Olig2tm2(TVA,cre)Rth

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Olig2 Mutation:	46 strains or lines available

Original:	J:139574 Schuller U, et al., Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. 2008 Aug 12;14(2):123-34
All:	54 reference(s)