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Tg(Tek-cre)2352Rwng
Transgene Detail
Summary
Symbol: Tg(Tek-cre)2352Rwng
Name: transgene insertion 2352, Rong Wang
MGI ID: MGI:3810530
Synonyms: Tg(Tek-cre)1Lfr, Tg(Tie2-Cre)2352, tie2-cre, Tie2Cre
Transgene: Tg(Tek-cre)2352Rwng  Location: unknown  
Alliance: Tg(Tek-cre)2352Rwng page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Tek-cre)2352Rwng expression driven by 1 gene
 
Mutation details: A transgenic construct containing sequence encoding cre under the control of of the mouse Tek, endothelial-specific receptor tyrosine kinase (also known as Tie2), promoter was introduced into FVB/N donor eggs. Founder line 2352 was subsequently established. Cre recombinase expression is detected in most endothelial cells and blood islands of the extraembryonic mesoderm by embryonic day (E)7.5, in the dorsal aorta by E8.5 and is very strong in head vasculature by E9. (J:104401)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tek (mouse)
Summary of all recombinase alleles driven by Tek.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:104401 Braren R, et al., Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol. 2006 Jan 2;172(1):151-62
All:  14 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory