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Pnmttm1(cre)Xbao
Targeted Allele Detail
Summary
Symbol: Pnmttm1(cre)Xbao
Name: phenylethanolamine-N-methyltransferase; targeted mutation 1, Xuping Bao
MGI ID: MGI:3810658
Gene: Pnmt  Location: Chr11:98277449-98279006 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance: Pnmttm1(cre)Xbao page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139932
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Pnmttm1(cre)Xbao expression driven by 1 gene
 
Mutation details: The 1.1 kb segment between the ATG translation start site of exon 1 and a ClaI site in exon 3 was replaced with a cre recombinase cDNA and a PGK-neo selection cassette. Enzyme activity was absent in the adrenal, heart, and brain of homozygotes. (J:139932)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pnmt (mouse)
Summary of all recombinase alleles driven by Pnmt.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pnmt Mutation:  13 strains or lines available
References
Original:  J:139932 Bao X, et al., Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse. Circulation. 2007 Aug 28;116(9):1024-31
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory