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Tg(Cryaa-cre,Tyr)39Mlr
Transgene Detail
Summary
Symbol: Tg(Cryaa-cre,Tyr)39Mlr
Name: transgene insertion 39, Mike Robinson
MGI ID: MGI:3811526
Synonyms: CPV2/Cre, MLR39-Cre
Transgene: Tg(Cryaa-cre,Tyr)39Mlr  Location: unknown  
Alliance: Tg(Cryaa-cre,Tyr)39Mlr page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Cryaa-cre,Tyr)39Mlr expression driven by 1 gene
 
Mutation details: A cre recombinase gene was driven by an alpha A crystallin promoter consisting of -282/+43 of the mouse Cryaa gene. Seven founder lines were generated using this construct, which in this line was coinjected with a tyrosinase minigene. Line 39 has expression of the transgene in lens fiber cells but not in the surrounding lens epithelium. Ectopic expression of the transgene was also detected in the retinal pigment epithelium and in the ciliary bodies of the eye. (J:90292)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cryaa (mouse)
Summary of all recombinase alleles driven by Cryaa.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:90292 Zhao H, et al., Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1930-9
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory