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Foxp3tm1(cre)Saka
Targeted Allele Detail
Summary
Symbol: Foxp3tm1(cre)Saka
Name: forkhead box P3; targeted mutation 1, Shimon Sakaguchi
MGI ID: MGI:3812203
Synonyms: FIC, Fox-IRES-Cre, Foxp3IRES-Cre
Gene: Foxp3  Location: ChrX:7445915-7461482 bp, + strand  Genetic Position: ChrX, 3.41 cM
Alliance: Foxp3tm1(cre)Saka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140085
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Foxp3tm1(cre)Saka expression driven by 1 gene
 
Mutation details: An IRES-cre cassette and a frt-flanked neomycin resistance marker were placed into the last exon of the gene immediately after the TGA stop codon. Hemizygous male mice had slightly lower amounts of the FoxP3 gene product than controls, as determined by flow cytometry on freshly isolated lymphocytes. Crossing with cre-reporter transgenic mice demonstrates that cre expression was confined to about 15% of CD4+ T cells and ~1.5% of CD8+ T cells. (J:140085)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxp3 (mouse)
Summary of all recombinase alleles driven by Foxp3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  58 strains or lines available
References
Original:  J:140085 Wing K, et al., CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008 Oct 10;322(5899):271-5
All:  30 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory