Tg(GFAP-cre/Esr1*,-lacZ)ASbk
Transgene Detail
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| Symbol: |
Tg(GFAP-cre/Esr1*,-lacZ)ASbk |
| Name: |
transgene insertion A, Suzanne J Baker |
| MGI ID: |
MGI:3813945 |
| Synonyms: |
GFAP-CreERTM, GFAP-CreERTMA, Tg(GFAP-cre/Esr1,lacZ)ASbk |
| Transgene: |
Tg(GFAP-cre/Esr1*,-lacZ)ASbk Location: unknown Genetic Position: Chr9, Syntenic
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| Alliance: |
Tg(GFAP-cre/Esr1*,-lacZ)ASbk page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(GFAP-cre/Esr1*,-lacZ)ASbk expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| human |
GFAP (2670) |
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Mutation details: This transgene consists of a 2.2 kb fragment of the human GFAP promoter, a cDNA encoding a fusion of cre and the mutated ligand binding domain of the human estrogen receptor, an IRES, cDNA encoding beta-galactosidase, and SV40 intronic sequence and polyadenylation signal. Transgene expression, assessed by beta-gal activity, is seen in Bergmann glia, neuronal precursors in the dentate gyrus, and cells in the subventricular zone surrounding the lateral ventricle. When crossed to reporter mice occasional tamoxifen-independent Cre mediated recombination is seen primarily in Bergmann glial cells.
(J:140270)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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GFAP
(human)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:140270 Chow LM, et al., Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res. 2008 Oct;17(5):919-28 |
| All: |
12 reference(s) |
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Analysis Tools
