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Scn11atm1Mdba
Targeted Allele Detail
Summary
Symbol: Scn11atm1Mdba
Name: sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, Mark Baker
MGI ID: MGI:3818305
Synonyms: Nav1.9-
Gene: Scn11a  Location: Chr9:119582829-119654522 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
Alliance: Scn11atm1Mdba page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141209
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 4 and 5 were replaced with a neo cassette eliminating the domain 1, S4 voltage sensor. The replacement causes a frameshift and introduce STOP codons in exon 6. The absence of full-length transcript expression was confirmed by RT-PCR. (J:141209)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn11a Mutation:  90 strains or lines available
References
Original:  J:141209 Ostman JA, et al., GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. J Physiol. 2008 Feb 15;586(4):1077-87
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory