Ret<tm1Giro> Targeted Allele Detail MGI Mouse (MGI:3819163)

Ret^tm1Giro
Targeted Allele Detail

Summary

Symbol:	Ret^tm1Giro
Name:	ret proto-oncogene; targeted mutation 1, Giovanni Romeo
MGI ID:	MGI:3819163
Synonyms:	ret^C620R
Gene:	Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance:	Ret^tm1Giro page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:141658
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted
Mutations:		Insertion, Nucleotide substitutions
		Mutation details: Nucleotide substitutions were used to create an amino acid substitution of arginnine for cysteine at position 20 (C620R). A floxed neo cassette inserted downstream of exon 10 was removed by transient cre expression in ES cells. (J:141658)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Ret^tm1Giro

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ret Mutation:	54 strains or lines available

References

Original:	J:141658 Yin L, et al., C620R mutation of the murine ret proto-oncogene: loss of function effect in homozygotes and possible gain of function effect in heterozygotes. Int J Cancer. 2007 Jul 15;121(2):292-300
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24