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Tg(Myh11-icre/ERT2)1Soff
Transgene Detail
Summary
Symbol: Tg(Myh11-icre/ERT2)1Soff
Name: transgene insertion 1, Stefan Offermanns
MGI ID: MGI:3819270
Synonyms: Myh11-CreERT2-Off, SMCCre, SMMHC-CreERT2, Tg(Myh11-cre/ERT2)1Soff, Tg(Myh11-cre/ESR1)1Soff
Transgene: Tg(Myh11-icre/ERT2)1Soff  Location: unknown  Genetic Position: ChrY, Syntenic
Alliance: Tg(Myh11-icre/ERT2)1Soff page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Myh11-icre/ERT2)1Soff expression driven by 1 gene
 
Mutation details: The mouse promoter from BAC clone 26630 was used to drive inducible icre expression in smooth muscle cells. An frt-flanked beta-lactamase gene contained within the cre/ESR1 cassette was removed by flp mediated recombination prior to micro-injection into fertilized oocytes. No line information was given. (J:141641, J:148424)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Myh11 (mouse)
Summary of all recombinase alleles driven by Myh11.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:141641 Wirth A, et al., G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan;14(1):64-8
All:  274 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory