Aiptm1Bra
Targeted Allele Detail
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| Symbol: |
Aiptm1Bra |
| Name: |
aryl-hydrocarbon receptor-interacting protein; targeted mutation 1, Christopher A Bradfield |
| MGI ID: |
MGI:3819941 |
| Synonyms: |
Ara9-, Ara9deltaCfx |
| Gene: |
Aip Location: Chr19:4164446-4175858 bp, - strand Genetic Position: Chr19, 3.82 cM
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| Alliance: |
Aiptm1Bra page
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Vessel caliber is decreased in Aiptm1Bra/Aiptm1Bra fetuses
Show the 5 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:141575
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Inversion
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Aiptm1Bra involves 1 genes/genome features (Aip)
View all
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Mutation details: Exons 3-6 were flanked by loxP sites and were inverted to an antisense orientation via homologous recombination (Aiptm2.1Bra
). This reverses the sequence of the C-terminal tetratricopeptide repeats and should result in the truncation of the protein. A neomycin cassette was also inserted following exon 6 and flanked on either side with Frt sites. The neomycin cassette was removed by mating with FLPeR mice (Gt(ROSA)26Sortm1(FLP1)Dym).
(J:141575)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Aip Mutation: |
26 strains or lines available
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| Original: |
J:141575 Lin BC, et al., Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem. 2007 Dec 7;282(49):35924-32 |
| All: |
2 reference(s) |
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Analysis Tools
