Tg(Cela1-cre/ERT2)1Stof Transgene Detail MGI Mouse (MGI:3820514)

Tg(Cela1-cre/ERT2)1Stof
Transgene Detail

Summary

Symbol:	Tg(Cela1-cre/ERT2)1Stof
Name:	transgene insertion 1, Doris A Stoffers
MGI ID:	MGI:3820514
Synonyms:	ElastaseCreERT2, Tg(Ela1-Cre/ESR1)1Stof
Transgene:	Tg(Cela1-cre/ERT2)1Stof Location: unknown
Alliance:	Tg(Cela1-cre/ERT2)1Stof page

Transgene
origin

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene
description

Transgene Type:

Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Tg(Cela1-cre/ERT2)1Stof expression driven by 1 gene

Mutation details: A transgenic construct containing the rabbit Beta-globin (RBG) intron, a sequence encoding Cre/ESR1 (Cre recombinase fused to a mutant estrogen receptor ligand-binding domain (ERT2)) under the control of the acinar cell-specific rat elastase 1 (Cela1) promoter, and a rabbit Beta-globin polyadenylation cassette was made and injected into B6SJLF1 oocytes. (J:121254)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cela1 (rat) Summary of all recombinase alleles driven by Cela1. Comparative matrix view of recombinase activities Alliance rat Cela1 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cela1-cre/ERT2)1Stof

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

Original:	J:121254 Desai BM, et al., Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest. 2007 Apr;117(4):971-7
All:	17 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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