Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Bhlha15tm3(cre/ERT2)Skz
Name:	basic helix-loop-helix family, member a15; targeted mutation 3, Stephen F Konieczny
MGI ID:	MGI:3821734
Synonyms:	Bhlha15tm3(cre/ESR1)Skz, Mist1creERT, Mist1-CreERT2, Mist1CreERT2
Gene:	Bhlha15  Location: Chr5:144127104-144131259 bp, + strand  Genetic Position: Chr5, 83.05 cM, cytoband G2-G3
Alliance:	Bhlha15tm3(cre/ERT2)Skz page

Germline Transmission:	Earliest citation of germline transmission: J:142189
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Bhlha15tm3(cre/ERT2)Skz expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Bhlha15 (MGI:891976)   Mutation details: The entire coding region was replaced with a cre-ESR1 (ERT2) fusion to allow for inducible cre expression in acinar cells. (J:142189)

Activity:	Tissue activity of this recombinase allele
Driver:	Bhlha15 (mouse) Summary of all recombinase alleles driven by Bhlha15. Comparative matrix view of recombinase activities Alliance mouse Bhlha15 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Bhlha15tm3(cre/ERT2)Skz

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bhlha15 Mutation:	15 strains or lines available

Original:	J:142189 Habbe N, et al., Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18913-8
All:	44 reference(s)