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Ncor1tm1Anh
Targeted Allele Detail
Summary
Symbol: Ncor1tm1Anh
Name: nuclear receptor co-repressor 1; targeted mutation 1, Anthony N Hollenberg
MGI ID: MGI:3821874
Synonyms: NCoRlox
Gene: Ncor1  Location: Chr11:62207132-62348200 bp, - strand  Genetic Position: Chr11, 38.08 cM, cytoband B2
Alliance: Ncor1tm1Anh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142045
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A loxP site was inserted upstream of exon 38 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 41. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 38 through 41 floxed. These exons encode two of the three receptor interacting domains (N2 and N3). (J:142045)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncor1 Mutation:  396 strains or lines available
References
Original:  J:142045 Astapova I, et al., The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19544-9
All:  14 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory