Aurka<Gt(XQ0149)Wtsi> Gene trapped Allele Detail MGI Mouse (MGI:3826513)

Aurka^{Gt(XQ0149)Wtsi}
Gene trapped Allele Detail

Summary

Symbol:	Aurka^{Gt(XQ0149)Wtsi}
Name:	aurora kinase A; gene trap XQ0149, Wellcome Trust Sanger Institute
MGI ID:	MGI:3826513
Gene:	Aurka Location: Chr2:172198110-172212455 bp, - strand Genetic Position: Chr2, 94.84 cM
Alliance:	Aurka^{Gt(XQ0149)Wtsi} page

Mutation
origin

Mutant Cell Line:	XQ0149
Germline Transmission:	Earliest citation of germline transmission: J:143099
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT0lxf

Mutation details: The gene trap vector pGT0lxf was inserted at intron 6. Neither the predicted fusion protein nor a truncated protein were detected. (J:143099)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Aurka^{Gt(XQ0149)Wtsi}

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Aurka Mutation:	40 strains or lines available

References

Original:	J:143099 Lu LY, et al., Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem. 2008 Nov 14;283(46):31785-90
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24