Aurka<Gt(XQ0149)Wtsi> Gene trapped Allele Detail MGI Mouse (MGI:3826513)

Aurka^{Gt(XQ0149)Wtsi}
Gene trapped Allele Detail

Summary

Symbol:	Aurka^{Gt(XQ0149)Wtsi}
Name:	aurora kinase A; gene trap XQ0149, Wellcome Trust Sanger Institute
MGI ID:	MGI:3826513
Gene:	Aurka Location: Chr2:172198110-172212455 bp, - strand Genetic Position: Chr2, 94.84 cM
Alliance:	Aurka^{Gt(XQ0149)Wtsi} page

Mutation
origin

Mutant Cell Line:	XQ0149
Germline Transmission:	Earliest citation of germline transmission: J:143099
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT0lxf

Mutation details: The gene trap vector pGT0lxf was inserted at intron 6. Neither the predicted fusion protein nor a truncated protein were detected. (J:143099)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Aurka^{Gt(XQ0149)Wtsi}

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Aurka Mutation:	40 strains or lines available

References

Original:	J:143099 Lu LY, et al., Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem. 2008 Nov 14;283(46):31785-90
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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