Nedd4<Gt(XA209)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3829272)

Nedd4^Gt(XA209)Byg
Gene trapped Allele Detail

Summary

Symbol:	Nedd4^Gt(XA209)Byg
Name:	neural precursor cell expressed, developmentally down-regulated 4; gene trap XA209, BayGenomics
MGI ID:	MGI:3829272
Synonyms:	Nedd4^-
Gene:	Nedd4 Location: Chr9:72569628-72657134 bp, + strand Genetic Position: Chr9, 40.08 cM
Alliance:	Nedd4^Gt(XA209)Byg page

Mutation
origin

Mutant Cell Line:	XA209
Germline Transmission:	Earliest citation of germline transmission: J:143560
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap

Mutation details: The gene trap vector, which contains a splice acceptor, IRES and beta-geo cassette, was inserted into intron 25. (J:143560)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

22 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Nedd4 Mutation:	116 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:143560 Yang B, et al., Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol. 2008 Dec;9(12):1356-63
All:	5 reference(s)

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