Lrig3<Gt(LST016)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3829384)

Lrig3^{Gt(LST016)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Lrig3^{Gt(LST016)Byg}
Name:	leucine-rich repeats and immunoglobulin-like domains 3; gene trap LST016, BayGenomics
MGI ID:	MGI:3829384
Gene:	Lrig3 Location: Chr10:125802088-125851228 bp, + strand Genetic Position: Chr10, 73.66 cM, cytoband D3
Alliance:	Lrig3^{Gt(LST016)Byg} page

Mutation
origin

Mutant Cell Line:	LST016
Germline Transmission:	Earliest citation of germline transmission: J:142510
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT2TMpfs Vector Type: secretory trap

Mutation details: The pGT2TMPFS gene trap vector containing a beta-geo cassette was inserted downstream of exon 2. Transcript expression is reduced to 3% of wild-type as determined by quantitative RT-PCR. This allele is severely hyppomorphic. (J:67920, J:142510)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Lrig3 Mutation:	64 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:67920 Leighton PA, et al., Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 2001 Mar 8;410(6825):174-9
All:	3 reference(s)

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